alexa MALDI-TOF MS detection of carbapenemase activity in clinical isolates of Enterobacteriaceae spp., Pseudomonas aeruginosa, and Acinetobacter baumannii compared against the Carba-NP assay.


Journal of Antimicrobial Agents

Author(s): Chong PM, McCorrister SJ, Unger MS, Boyd DA, Mulvey MR,

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Abstract MALDI-TOF MS detection of carbapenemase-activity in Gram-negative bacteria was compared against the Carba-NP assay. MALDI-TOF MS detected activity from 99\% of the strains, from all types of carbapenemase (200/202), while Carba-NP assays detected activity from 85\% (45/53) of the tested isolates and could not consistently identify OXA- or GES carbapenemase activity. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved. This article was published in J Microbiol Methods and referenced in Journal of Antimicrobial Agents

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