Author(s): Aluisio A, Richardson BA, Bosire R, JohnStewart G, MboriNgacha D,
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Abstract OBJECTIVE: To investigate the relationship between male involvement in prevention of mother-to-child HIV transmission services and infant HIV acquisition and mortality, a prospective cohort study was undertaken between 1999 and 2005 in Nairobi, Kenya. METHODS: HIV-infected pregnant women were enrolled and followed with their infants for 1 year with infant HIV DNA testing at birth, 1, 3, 6, 9, and 12 months postpartum. Women were encouraged to invite male partners for prevention counseling and HIV testing. RESULTS: Among 456 female participants, 140 partners (31\%) attended the antenatal clinic. Eighty-two (19\%) of 441 infants tested were HIV infected by 1 year of age. Adjusting for maternal viral load, vertical transmission risk was lower among women with partner attendance compared with those without [adjusted hazard ratio (aHR) = 0.56, 95\% confidence interval (CI): 0.33 to 0.98; P = 0.042] and among women reporting versus not reporting previous partner HIV testing (aHR = 0.52, 95\% CI: 0.32 to 0.84; P = 0.008). The combined risk of HIV acquisition or infant mortality was lower with male attendance (aHR = 0.55; 95\% CI: 0.35 to 0.88; P = 0.012) and report of prior male HIV testing (aHR = 0.58; 95\% CI: 0.34 to 0.88; P = 0.01) when adjusting for maternal viral load and breastfeeding. CONCLUSIONS: Including men in antenatal prevention of mother-to-child HIV transmission services with HIV testing may improve infant health outcomes.
This article was published in J Acquir Immune Defic Syndr
and referenced in Journal of Molecular Biomarkers & Diagnosis