alexa Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study.
Genetics

Genetics

Advancements in Genetic Engineering

Author(s): Dirix M, van Becelaere T, Berkenbosch L, van Baren R, Wijnen RM,

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Abstract BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80\% and 58\% after one and two years in SCT versus 100\% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. Copyright © 2015 Elsevier Inc. All rights reserved. This article was published in J Pediatr Surg and referenced in Advancements in Genetic Engineering

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