alexa Management of accidental exposure to Ebola virus in the biosafety level 4 laboratory, Hamburg, Germany.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Gnther S, Feldmann H, Geisbert TW, Hensley LE, Rollin PE, , Gnther S, Feldmann H, Geisbert TW, Hensley LE, Rollin PE,

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Abstract A needlestick injury occurred during an animal experiment in the biosafety level 4 laboratory in Hamburg, Germany, in March 2009. The syringe contained Zaire ebolavirus (ZEBOV) mixed with Freund's adjuvant. Neither an approved treatment nor a postexposure prophylaxis (PEP) exists for Ebola hemorrhagic fever. Following a risk-benefit assessment, it was recommended the exposed person take an experimental vaccine that had shown PEP efficacy in ZEBOV-infected nonhuman primates (NHPs) [12]. The vaccine, which had not been used previously in humans, was a live-attenuated recombinant vesicular stomatitis virus (recVSV) expressing the glycoprotein of ZEBOV. A single dose of 5 × 10(7) plaque-forming units was injected 48 hours after the accident. The vaccinee developed fever 12 hours later and recVSV viremia was detectable by polymerase chain reaction (PCR) for 2 days. Otherwise, the person remained healthy, and ZEBOV RNA, except for the glycoprotein gene expressed in the vaccine, was never detected in serum and peripheral blood mononuclear cells during the 3-week observation period. This article was published in J Infect Dis and referenced in Journal of Bioterrorism & Biodefense

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