Author(s): Osafune K, Caron L, Borowiak M, Martinez RJ, FitzGerald CS,
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Abstract The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific lineages, often with >100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic differentiation and HUES 3 for cardiomyocyte generation. These non-trivial differences in developmental potential among hES cell lines point to the importance of screening and deriving lines for lineage-specific differentiation.
This article was published in Nat Biotechnol
and referenced in Journal of Stem Cell Research & Therapy