alexa Mass spectrometry in clinical proteomics - from the present to the future.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Palmblad M, Tiss A, Cramer R

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Abstract MS is an important analytical tool in clinical proteomics, primarily in the disease-specific discovery, identification and characterisation of proteomic biomarkers and patterns. MS-based proteomics is increasingly used in clinical validation and diagnostic method development. The latter departs from the typical application of MS-based proteomics by exchanging some of the high performance of analysis for the throughput, robustness and simplicity required for clinical diagnostics. Although conventional MS-based proteomics has become an important field in clinical applications, some of the most recent MS technologies have not yet been extensively applied in clinical proteomics. In this review, we will describe the current state of MS in clinical proteomics and look to the future of this field. Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This article was published in Proteomics Clin Appl and referenced in Journal of Cytology & Histology

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