alexa Mastication influences the survival of newly generated cells in mouse dentate gyrus.
Medicine

Medicine

Anatomy & Physiology: Current Research

Author(s): Mitome M, Hasegawa T, Shirakawa T

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Abstract We examined the effects of soft food and tooth loss on neurogenesis in the adult dentate gyrus. Four-week-old mice were subjected to a powder diet for 10 weeks with or without removal of molars. They received a daily injection of bromodeoxyuridine (BrdU) at 14 weeks of age for 12 consecutive days. The number of BrdU-positive cells in the dentate gyrus of these mice did not differ from that of control at 1 day after the last BrdU injection. However, the BrdU-positive cells in these mice showed a larger reduction in number than in control at 5 weeks after the BrdU injection and the ratio of neurons to BrdU-positive cells decreased in the molarless mice. These results suggest that mastication influences the survival of newly generated cells in the adult dentate gyrus.
This article was published in Neuroreport and referenced in Anatomy & Physiology: Current Research

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