alexa Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Rai V, Yadav U, Kumar P, Yadav SK, Mishra OP

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Abstract BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate donates methyl group for the methylation of homocysteine to methionine. Several studies have investigated maternal MTHFR C677T polymorphism as a risk factor for DS, but the results were controversial and inconclusive. To come into a conclusive estimate, authors performed a meta-analysis. AIM: A meta-analysis of published case control studies was performed to investigate the association between maternal MTHFR C677T polymorphism and Down syndrome. METHODS: PubMed, Google Scholar, Elsevier, Springer Link databases were searched to select the eligible case control studies using appropriate keywords. The pooled odds ratio (OR) with 95\%confidence interval were calculated for risk assessment. RESULTS: Thirty four studies with 3,098 DS case mothers and 4,852 control mothers were included in the present meta-analysis. The pooled OR was estimated under five genetic models and significant association was found between maternal MTHFR 677C>T polymorphism and Down syndrome under four genetic models except recessive model (for T vs. C, OR = 1.26, 95\% CI = 1.09-1.46, p = 0.001; for TT vs. CC, OR = 1.49, 95\% CI = 1.13-1.97, p = 0.008; for CT vs. CC, OR = 1.29, 95\% CI = 1.10-1.51, p = 0.001; for TT+CT vs. CC, OR = 1.35, 95\% CI = 1.13-1.60, p = 0.0008; for TT vs. CT+CC, OR = 0.76, 95\% CI = 0.60-0.94, p = 0.01). CONCLUSION: The results of the present meta-analysis support that maternal MTHFR C677T polymorphism is a risk factor for DS- affected pregnancy.
This article was published in PLoS One and referenced in Journal of Genetic Syndromes & Gene Therapy

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