alexa Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.
Reproductive Medicine

Reproductive Medicine

Journal of Pregnancy and Child Health

Author(s): DominguezSalas P, Moore SE, Baker MS, Bergen AW, Cox SE,

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Abstract In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.
This article was published in Nat Commun and referenced in Journal of Pregnancy and Child Health

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