alexa Maximal thymectomy in children with myasthenia gravis.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Essa M, ElMedany Y, Hajjar W, Hariri Z, AlMulhim F,

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Abstract OBJECTIVES: We performed this study to evaluate the benefit of thymectomy in children with myasthenia gravis (MG). METHODS: Over a period of 15 years from 1986 to 2001, we collected data on 30 children with MG and retrospectively reviewed the outcome of maximal thymectomy. RESULTS: There were 23 females and seven males with a mean age of 13.2 years (range 4-16). The mean duration of the disease was 19.3 months (range 2-144). According to Osserman classification, there were 14 children in class II; 12 in class III; and four children in class IV. One child in class IV required postoperative ventilation and one was re-explored to drain a pericardial effusion secondary to central line leak. We found ectopic thymic tissue in 10 cases (33.3\%). During a mean follow-up period of 53.5 months (range 9-180), complete remission was noted in 13 children (43.4\%) and improvement in 14 (46.6\%). The remaining three children (10\%) did not improve following surgery. Univariate analysis (P < 0.05) showed that ectopic thymic tissue is a significant prognostic factor for outcome. CONCLUSION: Maximal thymectomy appears to provide a high rate of remission and improvement in children with MG. However, the presence of ectopic thymic tissue has poor prognostic value.
This article was published in Eur J Cardiothorac Surg and referenced in Journal of Addiction Research & Therapy

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