alexa MDM2 309 polymorphism is associated with missed abortion.
Genetics & Molecular Biology

Genetics & Molecular Biology

Hereditary Genetics: Current Research

Author(s): Fang Y, Kong B, Yang Q, Ma D, Qu X

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Abstract BACKGROUND: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion. METHODS: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion. RESULTS: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95\% confidence interval (CI): 1.207-3.878) and villous samples (P = 0.043; OR: 2.767; 95\% CI: 1.092-7.011). CONCLUSIONS: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion. This article was published in Hum Reprod and referenced in Hereditary Genetics: Current Research

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