Author(s): Alessi DR, Cohen P
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Abstract The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.
This article was published in Curr Opin Genet Dev
and referenced in Metabolomics:Open Access