alexa Mechanism of DNA double-strand break repair by non-homologous end joining.
Neurology

Neurology

Journal of Neurological Disorders

Author(s): Hefferin ML, Tomkinson AE

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Abstract The repair of DNA double-strand breaks (DSBs) is critical for maintaining genome stability. Although the non-homologous end joining (NHEJ) pathway frequently results in minor changes in DNA sequence at the break site and occasionally the joining of previously unlinked DNA molecules, it is a major contributor to cell survival following exposure of mammalian cells to agents that cause DSBs. This repair mechanism is conserved in lower eukaryotes and in some prokaryotes although the majority of DSBs are repaired by recombinational repair pathways in these organisms. Here we will describe the biochemical properties of NHEJ factors from bacteria, Saccharomyces cerevisiae and mammals, and how physical and functional interactions among these factors co-ordinate the repair of DSBs. This article was published in DNA Repair (Amst) and referenced in Journal of Neurological Disorders

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