Author(s): Orr AW, Helmke BP, Blackman BR, Schwartz MA, Orr AW, Helmke BP, Blackman BR, Schwartz MA
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Abstract Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.
This article was published in Dev Cell
and referenced in Immunogenetics: Open Access