alexa Mechanisms of regulated unconventional protein secretion
Cardiology

Cardiology

Angiology: Open Access

Author(s): Nickel W

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Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)-Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing proteins have been shown to reach the cell surface by non-conventional transport pathways. The mechanisms and molecular components of unconventional protein secretion are beginning to emerge, including a role for caspase 1 and for the peripheral Golgi protein GRASP, which could function as a plasma membrane tether for membrane compartments during specific stages of development.

This article was published in Nat Rev Mol Cell Biol and referenced in Angiology: Open Access

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