alexa Mechanotransduction in the Immune System


Immunogenetics: Open Access

Author(s): Michelle L Previtera

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Regulation of the immune system has been heavily investigated from a biological perspective due to the biological nature of inflammatory stimulants and pathogens. However, more studies have shown that biophysical cues generated by normal physiological events or diseases regulate the immune system. In fact, a new paradigm is emerging in which data shows that normal physiological mechanical stimuli suppress inflammation whereas pathophysiological mechanical stimuli trigger inflammation. In this review, evidence supporting this paradigm is provided. Specifically, physiological and pathophysiological mechanical stimuli are described, the effects of mechanical stimuli on innate and adaptive immune system function are discussed, and the mechanotransduction pathways that regulate white blood cell behavior are explained. By understanding both the biological and physical stimulants that regulate the immune system, novel and more effective drugs can be developed that reduce inflammation.

This article was published in Cellular and Molecular Bioengineering and referenced in Immunogenetics: Open Access

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