Author(s): Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ, Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ
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Abstract In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the alpha-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of alpha-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte.
This article was published in Biochem Biophys Res Commun
and referenced in Dermatology and Dermatologic Diseases