alexa Meta-analysis of association between the -1438A G (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder.
Medicine

Medicine

Evidence based Medicine and Practice

Author(s): Jin C, Xu W, Yuan J, Wang G, Cheng Z, Jin C, Xu W, Yuan J, Wang G, Cheng Z

Abstract Share this page

Abstract OBJECTIVES: Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of approximately 10-15\%. Previous pharmacological studies suggested that the serotonin 2A receptor (5-HTR2A) was one of the major pharmacological therapeutic targets for MDD. Recently, genetic studies investigated the association between the polymorphism rs6311 of the 5-HTR2A gene and MDD. However, the results of these studies were inconsistent. To evaluate these conflicting findings, we performed the current meta-analysis. METHODS: Eleven articles form PubMed and Chinese National Knowledge Infrastructure databases were selected including 1491 patients and 2937 controls for the meta-analysis through assessing in detail. All statistical analyses were performed by RevMan (v.5·1) program. RESULTS: No significant association between the 5-HTR2A gene SNP rs6311 and the risk of MDD was observed by four genetic models in the current meta-analysis (P = 0·12 for A versus G; P = 0·11 for AA versus GG; P = 0·06 for AA+AG versus GG; P = 0·24 for AG+GG versus AA). The calculated generalized odds ratio also revealed that the SNP rs6311 did not confer an increased risk to MDD. Moreover, the sensitivity analysis indicated that the result of meta-analysis is instable. CONCLUSIONS: Although the current meta-analysis indicated that the SNP rs6311 within the 5-HTR2A gene may be not associated with an increased risk for MDD, the results require further study to acquire more direct evidence. This article was published in Neurol Res and referenced in Evidence based Medicine and Practice

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords