alexa Meta-analysis of epidemiologic dose-response data.
Mathematics

Mathematics

Journal of Biometrics & Biostatistics

Author(s): Berlin JA, Longnecker MP, Greenland S

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Abstract We discuss methods for summarizing epidemiologic studies of dose-response. The data from such a study typically appear as a series of dose-specific relative risks, with one category serving as the common reference group. We present methods for estimating the dose-response parameters from single and multiple study reports, for assigning levels to exposure categories when modeling relative risks, and for investigating the effects of study design and subject characteristics on dose-response curves. Finally, we discuss the choice of fixed vs random effects models. We illustrate our points with data from case-control studies of the relation between duration of oral contraceptive use and risk of breast cancer.
This article was published in Epidemiology and referenced in Journal of Biometrics & Biostatistics

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