alexa Meta-analysis of statin effects in women versus men.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Kostis WJ, Cheng JQ, Dobrzynski JM, Cabrera J, Kostis JB

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Abstract OBJECTIVES: The aim of this study was to evaluate the effect of statins in decreasing cardiovascular events in women and men. BACKGROUND: Published data reviews have suggested that statins might not be as effective in women as in men in decreasing cardiovascular events. METHODS: Published data searches and contacts with investigators identified 18 randomized clinical trials of statins with sex-specific outcomes (N = 141,235, 40,275 women, 21,468 cardiovascular events). Odds ratios (ORs) and 95\% confidence intervals (CIs) for cardiovascular events were calculated for women and men separately with random effects meta-analyses. RESULTS: The cardiovascular event rate was lower among those randomized to statin intervention than in those randomized to control (low-dose statin in 4 studies, placebo in 11 studies, usual care in 3 studies) and similar in women and men (OR: 0.81, 95\% CI: 0.75 to 0.89; p < 0.0001, and OR: 0.77, 95\% CI: 0.71 to 0.83, p < 0.0001, respectively). The benefit of statins was statistically significant in both sexes, regardless of the type of control, baseline risk, or type of endpoint and in both primary and secondary prevention. All-cause mortality was also lower with statin therapy both in women and men without significant interaction by sex (p for interaction = 0.4457). CONCLUSIONS: Statin therapy is associated with significant decreases in cardiovascular events and in all-cause mortality in women and men. Statin therapy should be used in appropriate patients without regard to sex. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. This article was published in J Am Coll Cardiol and referenced in Journal of Diabetes & Metabolism

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