alexa Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis.


Journal of Hepatology and Gastrointestinal disorders

Author(s): Moawad FJ, Cheatham JG, DeZee KJ

Abstract Share this page

Abstract BACKGROUND: Oesophageal dilation is one of the most effective options in the management of symptoms of eosinophilic oesophagitis (EoE). However, earlier reports described an increased rate of complications. AIM: To perform a meta-analysis of population-based studies of the risks associated with dilation and the clinical efficacy and duration of response to dilation in EoE. METHODS: Using MEDLINE and EMBASE, a systematic search was performed for published articles since 1977 describing cohort or randomised controlled trials of dilation in EoE. Summary estimates, including 95\% confidence interval (CI), were calculated for the occurrence of complications associated with dilations (perforations, haemorrhage, chest pain, lacerations) and percentage of patients with symptom improvement following dilation. Heterogeneity was calculated using the I² statistic. RESULTS: The search resulted in 232 references, of which 9 studies were included in the final analysis. The studies described 860 EoE patients, of whom 525 patients underwent at least one oesophageal dilation and a total of 992 dilations. There were three cases of perforation (95\% CI 0-0.9\%, I² 0\%) and one haemorrhage (95\% CI 0-0.8\%, I² 0\%). Six studies reported postprocedural chest pain in 2\% of cases (95\% CI 1-3, I² 53\%). Clinical improvement from dilation occurred in 75\% of patients (95\% CI 58-93\%, I² 86\%). CONCLUSIONS: Dilation in patients with eosinophilic oesophagitis is a safe procedure with a low rate of serious complications (<1\%), and seems to result in at least a short-term improvement of symptoms in the majority of patients. Published 2013. This article is a US Government work and is in the public domain in the USA. This article was published in Aliment Pharmacol Ther and referenced in Journal of Hepatology and Gastrointestinal disorders

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version