alexa Metabolic syndrome: an emerging public health problem in Iranian women: Isfahan Healthy Heart Program.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Sarrafzadegan N, Kelishadi R, Baghaei A, Hussein Sadri G, Malekafzali H,

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Abstract OBJECTIVES: To determine the gender-specific prevalence of the metabolic syndrome (Met S) in a representative sample of Iranian adults, and to identify some possible related lifestyle factors. METHODS: As the baseline survey of a community-based interventional program entitled Isfahan Healthy Heart Program, we performed this cross-sectional study on 12,514 adults (> or =19 years) living in urban and rural areas of 3 cities in Iran. We assessed the prevalence of the Met S (according to the ATP III criteria) as well as dietary intake (based on food frequency questionnaire) and physical activity habits of all of the participants. We also evaluated dietary intake at the micronutrient level by using a one-day food record in a sub-sample of 2000 participants. RESULTS: The age-adjusted prevalence of Met S was 23.3\%, with a higher prevalence in women compared to men (35.1\% vs. 10.7\%, P<0.05) and in urban residents compared to rural residents (24.2\% vs. 19.5\%, P<0.05). In all age groups and in both urban and rural areas, the Met S affected a significantly larger number of women than men. Among women, abdominal obesity (71.7\%) was more prevalent followed by low HDL-C (60.9\%) and hypertriglyceridemia (56.6\%), whereas among men, the most frequent components were hypertriglyceridemia (49.1\%) and low HDL-C (35.1\%), respectively. Abdominal obesity was nearly six times as prevalent in women as in men (71.7\% vs. 12\%, P<0.05) and had a significant association with metabolic disorders even after adjustment for age, sex and the living area. In general, dietary intake had no effect on the prevalence of Met S. The prevalence of Met S in subjects with a sedentary lifestyle was significantly higher than in active subjects of both genders (25.6\% vs. 14.4\%, respectively, P<0.05). CONCLUSION: The Met S is highly prevalent in the Iranian population, notably in women living in urban areas. Abdominal obesity and dyslipidemia characterize this syndrome. Implementing community-based strategies for lifestyle change is of great significance. This article was published in Int J Cardiol and referenced in Journal of Molecular and Genetic Medicine

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