alexa Metabolic syndrome is associated with high grade Gleason score when prostate cancer is diagnosed on biopsy.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): De Nunzio C, Freedland SJ, Miano R, Trucchi A, Cantiani A,

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Abstract BACKGROUND: To evaluate the association between metabolic syndrome (MS) and prostate cancer diagnosis and grade in patients undergoing prostate biopsy. METHODS: From 2009 onwards, a consecutive series of patients undergoing 12-core prostate biopsy for PSA value ≥4 ng/ml and/or positive digital rectal examination (DRE) were prospectively enrolled. Body mass index (BMI), waist circumferences, and blood pressure were measured before the biopsy. Blood samples were tested for: PSA, fasting glucose, triglycerides, and cholesterol HDL. MS presence was defined according to Adult Treatment Panel III criteria. RESULTS: One hundred ninety five patients were enrolled with a median age and PSA of 69 years and 5.6 ng/ml respectively. Median BMI was 27.6 kg/m(2) with 64 patients (33\%) being classified as obese (BMI ≥ 30 kg/m(2) ). Eighty-six patients (44\%) had MS. Eighty-three patients (43\%) had cancer on biopsy; 37 (45\%) with MS and 46 (55\%) without (P = 0.48). PSA was independently associated with higher risk of cancer (OR 1.12/1 U PSA, P = 0.01). Out of 83 patients with prostate cancer, 42 (51\%) had Gleason score 6 (12 (28.5\%) presented a MS) and 41 (49\%) a Gleason score ≥7 (25 (61\%) presented a MS). The presence of MS was not associated with an increased risk prostate cancer (OR: 0.97, P = 0.94) but with an increased risk of Gleason ≥7 (OR: 3.82; P = 0.013). CONCLUSIONS: In our single center study, MS is associated with an increased risk of high grade Gleason score when prostate cancer is diagnosed on biopsy. However, these results should be confirmed in a larger multicenter study. . Copyright © 2011 Wiley-Liss, Inc. This article was published in Prostate and referenced in Journal of Cytology & Histology

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