alexa Metagenomics--the key to the uncultured microbes.
Microbiology

Microbiology

Journal of Microbial & Biochemical Technology

Author(s): Streit WR, Schmitz RA

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Abstract It is widely accepted that up to 99.8\% of the microbes present in many environments are not readily culturable. 'Metagenome technology' tries to overcome this bottleneck by developing and using culture-independent approaches. From the outset, metagenome-based approaches have led to the accumulation of an increasing number of DNA sequences, but until this time the sequences retrieved have been those of uncultured microbes. These genomic sequences are currently exploited for novel biotechnological and pharmaceutical applications and to increase our knowledge on microbial ecology and physiology of these microbes. Using the metagenome sequences to fully understand how complex microbial communities function and how microbes interact within these niches represents a major challenge for microbiologists today. This article was published in Curr Opin Microbiol and referenced in Journal of Microbial & Biochemical Technology

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