Author(s): Wu AJ, Mehra R, Hafez K, Wolf JS Jr, Kunju LP
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Abstract AIMS: To review our experience with metastases to the kidney in surgical pathology material. METHODS AND RESULTS: The clinicopathological features of all metastases to the kidney in surgical pathology cases between May 1987 and May 2013 at our institution were reviewed. Autopsy cases were excluded. Forty-three cases (16 nephrectomies, 25 biopsies, and two fine needle aspirations) were included; the primary malignancy was diagnosed prior to/concurrently with the metastasis in nearly all cases. Common primary sites included the lung, breast, female genital tract, and head and neck; the majority were carcinomas. A primary renal tumour was suspected prior to the pathological diagnosis in 35\% of cases. Unusual features included: common unilateral (77\%) and unifocal (70\%) involvement, lack of other distant organ metastases (37\%), >10 years between primary and metastasis diagnoses (19\%), lack of a discrete mass (5\%), and renal vein extension (19\% of resections). The most common dilemma was excluding urothelial or high-grade renal cell carcinoma; however, metastases from the thyroid commonly mimicked low-grade renal cell carcinomas. CONCLUSIONS: In surgical pathology material, metastases to the kidney most commonly present as solitary unilateral masses, and in a substantial subset of cases mimic a primary renal tumour. © 2014 John Wiley & Sons Ltd.
This article was published in Histopathology
and referenced in Journal of Clinical Case Reports