Author(s): Gregoire C, Muller G, Machiels JP, Goeminne JC
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Abstract About 3-5\% of metastatic cancers originate from an unknown primary origin. Some have a signet-ring cell (SRC) component. We report the medical history of three patients with SRC carcinoma expressing both the oestrogen (ER) and progesterone receptors (PR). Although no primary breast cancer could be identified, we considered these three patients as having metastatic breast cancer. All of them were therefore treated with standard breast anti-hormonal therapies and all demonstrated benefit. The pitfalls of clinical presentation, diagnostic work-up, and treatment are discussed.
This article was published in Acta Clin Belg
and referenced in JBR Journal of Clinical Diagnosis and Research