Author(s): Ramasamy R, Yan SF, Schmidt AM
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Abstract The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.
This article was published in Cell
and referenced in Biochemistry & Pharmacology: Open Access