alexa Methylprednisolone as palliative therapy for female terminal cancer patients. The Methylprednisolone Female Preterminal Cancer Study Group.


Journal of Cancer Science & Therapy

Author(s): Popiela T, Lucchi R, Giongo F

Abstract Share this page

Abstract A total of 173 female terminal cancer patients were randomized to treatment with daily 125 mg infusions of methylprednisolone sodium succinate or a matching placebo for a period of 8 consecutive weeks. Data were collected relative to quality of life, investigator assessment of efficacy and cause and time of death within the 8-week treatment period. Significant improvement in quality of life was reported across the 8-week follow-up period in the steroid group. Investigator global assessment of efficacy significantly favored the steroid-treatment patients. There were no significant differences between treatment groups with regard to overall mortality rates or time to death. The total number of reported adverse events did not differ significantly between treatment groups. However, significantly more steroid patients reported gastrointestinal and cardiovascular events. The severity and outcome of these events did not differ from the placebo patients. The results of this study confirm previous reports of steroid efficacy in improving quality of life in terminal cancer patients. The absence of any untoward effect on mortality and the favorable safety profile support the use of methylprednisolone as palliative therapy for terminal cancer patients.
This article was published in Eur J Cancer Clin Oncol and referenced in Journal of Cancer Science & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version