Author(s): Imazawa M, Hatanaka Y
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Abstract A fast and reliable method for the MEKC separation and determination of benzodiazepine antipileptics and their active metabolites in serum has been developed, using a separation buffer composed of borate (pH 9.5), SDS (18 mM), and acetonitrile (14\%) as an organic modifier. The method is sensitive enough to be used clinically with a precision of less than 3\% for the analysis of nitrazepam, clonazepam, clobazam, diazepam and their desmethyl metabolites in serum.
This article was published in J Pharm Biomed Anal
and referenced in Pharmaceutica Analytica Acta