alexa Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, , Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G,

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Abstract Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology remains obscure. Here we show that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation. Circulating lipopolysaccharide, which we used as an indicator of microbial translocation, was significantly increased in chronically HIV-infected individuals and in simian immunodeficiency virus (SIV)-infected rhesus macaques (P
  • DOI: 10.1038/nm1511
  • This article was published in Nat Med and referenced in Journal of AIDS & Clinical Research

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