alexa Micromolar zinc affects endonucleolytic activity in hydrogen peroxide-mediated apoptosis.


Journal of Clinical & Experimental Dermatology Research

Author(s): Marini M, Musiani D

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When damaged by hydrogen peroxide, peripheral blood lymphocytes undergo cell death by apoptosis in the absence of internucleosomal DNA cleavage, while, in the same cells, other apoptosis-inducing treatments bring DNA cleavage to completion. However, the formation of internucleosomal DNA fragments is readily obtained if cells are pretreated with a divalent metal chelator, TPEN, at micromolar concentrations. Since the coadministration of equimolar zinc concentrations abrogates the formation of the ladder, a zinc-inhibitable endonucleolytic activity is accounted for the effect. Most notably, subtraction of zinc ions does not increase the percentage of cells undergoing apoptosis, but rather results in a rescue from death.

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This article was published in Exp Cell Res. and referenced in Journal of Clinical & Experimental Dermatology Research

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