alexa MicroRNA biogenesis pathways in cancer.


Journal of Gastrointestinal Cancer and Stromal Tumors

Author(s): Lin S, Gregory RI

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MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.

This article was published in Nat Rev Cancer. and referenced in Journal of Gastrointestinal Cancer and Stromal Tumors

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