alexa Micro-RNA in disease and gene therapy.
Genetics & Molecular Biology

Genetics & Molecular Biology

Hereditary Genetics: Current Research

Author(s): Lundstrom K

Abstract Share this page

Abstract The key regular functions of microRNAs (miRNAs) were only discovered a few years ago, when it became evident that miRNAs play important roles in gene regulation. Today, more than 700 miRNAs have been identified from the human genome. Because of their regulatory functions in transcription, signal transduction, cell cycle regulation, proliferation, cell growth, apoptosis, cell metabolism and neurogenesis, malfunctioning miRNAs have been suggested to affect a number of diseases. Indeed, absence of miRNAs or their mutations has been associated with various types of cancers and other diseases such as neurodegenerative, autoimmune, cardiovascular, infectious, metabolic and oncologic diseases. This has been confirmed by genetic analysis of patient samples. The disease association has attracted potential diagnostic and therapeutic applications of miRNAs. A significant issue to achieve successful therapy is the delivery of miRNAs as problems of targeted and long-lasting presence of miRNA exist. Different approaches have included the modification of miRNAs and the use of viral delivery vectors.
This article was published in Curr Drug Discov Technol and referenced in Hereditary Genetics: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords