alexa MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Bian K, Fan J, Zhang X, Yang XW, Zhu HY,

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Abstract Previous studies have shown that miR-203 acts as a tumor-suppressive microRNA in various cancers, but its roles in laryngeal carcinoma are still contradicted. Here, we found that miR-203 inhibited the growth of laryngeal cancer cells and survivin was a direct target of miR-203. Moreover, silencing of survivin recapitulated the effect of miR-203 on cell cycle progression, whereas overexpression of survivin reversed this effect. Additionally, qRT-PCR showed the reciprocal relationship between miR-203 and survivin in laryngeal cancer tissues. These findings indicate that miR-203 inhibits the proliferation of laryngeal carcinoma cells by directly targeting survivin, suggesting its application in anti-cancer therapeutics. Copyright © 2012. Published by Elsevier B.V. This article was published in FEBS Lett and referenced in Biochemistry & Analytical Biochemistry

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