Author(s): Leucci E, Patella F, Waage J, Holmstrm K, Lindow M,
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Abstract microRNAs regulate the expression of over 60\% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.
This article was published in Sci Rep
and referenced in Journal of Cytology & Histology
- Ji-Zhong Bai
Astrocytic contribution to deficient Ca2+ signalling and oxidative stress mediated by TRPV4 channels in A40-induced hippocampal cell death
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