Author(s): Yan CG, Cai XM, Wang QF, Wang TY, Zheng M
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Abstract A one-pot, effective synthesis of pyridines by a modified Kröhnke procedure is described. Polysubstituted annulated pyridines were synthesized in high yields by four-component, one-pot cyclocondensation reactions of N-phenacylpyridinium bromide, aromatic aldehydes, acetophenones or cyclic ketones in the presence of ammonium acetate and acetic acid, assisted by microwave irradiation. In this procedure, cyclic ketones with two alpha-CH(2) groups yield annulated pyridines with additional alpha-benzylidene groups, which are derived in situ from double aldol condensation of cyclic ketones with two moles of aromatic aldehydes.
This article was published in Org Biomol Chem
and referenced in Medicinal Chemistry