alexa Microwave-assisted synthesis of 2,4,5-triaryl-imidazole; a novel thermally induced N-hydroxyimidazole N-O bond cleavage.


Organic Chemistry: Current Research

Author(s): Sparks RB, Combs AP

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Abstract [reaction: see text] 2,4,5-Triaryl-imidazoles were synthesized directly from the keto-oxime in moderate to good yields via cyclization to the N-hydroxyimidazole and an unprecedented in situ thermal reduction of the N-O bond upon microwave irradiation at 200 degrees C for 20 min. This article was published in Org Lett and referenced in Organic Chemistry: Current Research

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