alexa Miliary tuberculosis and acute respiratory distress syndrome


Mycobacterial Diseases

Author(s): Kim JY, Park YB, Kim YS, Kang SB, Shin JW

Abstract Share this page

OBJECTIVE: Miliary tuberculosis is a life-threatening disease caused by the haematogenous spread of Mycobacterium tuberculosis. We evaluated the clinical manifestations of 34 patients with miliary tuberculosis. DESIGN: A retrospective case review. RESULTS: The diagnosis of miliary tuberculosis was based on the identification of miliary nodules on chest radiography and one of the three following criteria: 1) acid-fast bacilli smear and/or culture positive in clinical specimens (22/34), 2) histopathological identification of TB granuloma (6/34), and 3) radiological and clinical improvement after anti-tuberculosis treatment (6/34). The median age (±SD) of the patients was 42.7 ± 21.6 years, with two peaks, in the age group 20–30 and in those over 60. There were 16 underlying diseases in 14 patients, of which liver cirrhosis was the most common. The drug sensitivity pattern was available for 17 isolates of M. tuberculosis: 14 were sensitive, while the other three were resistant to at least one anti-tuberculosis drug. Eight patients developed acute respiratory distress syndrome (ARDS), five of whom died during intensive care. Platelet count, serum albumin and liver enzyme level at the time of admission were significant factors both for ARDS development and for survival. CONCLUSION: ARDS caused by miliary TB is associated with a high fatality rate; scope remains for improvement in its management. Keywords: ARDS; ICU care; drug sensitivity; miliary tuberculosis Document Type: Regular Paper Affiliations: 1: Department of Internal Medicine, ChungAng University Medical College, Seoul, Republic of Korea 2: Department of Diagnostic Radiology, ChungAng University Medical College, Seoul, Republic of Korea Publication date: April 1, 2003 More about this publication? We recommend

  • To read the full article Visit
  • Subscription
This article was published in The International Journal of Tuberculosis and Lung Disease and referenced in Mycobacterial Diseases

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version