alexa Mimicking nanofibrous hybrid bone substitute for mesenchymal stem cells differentiation into osteogenesis.
Toxicology

Toxicology

Journal of Drug Metabolism & Toxicology

Author(s): Gandhimathi C, Venugopal J, Ravichandran R, Sundarrajan S, Suganya S, , Gandhimathi C, Venugopal J, Ravichandran R, Sundarrajan S, Suganya S,

Abstract Share this page

Abstract Mimicking hybrid extracellular matrix is one of the main challenges for bone tissue engineering (BTE). Biocompatible polycaprolactone/poly(α,β)-DL-aspartic acid/collagen nanofibrous scaffolds were fabricated by electrospinning and nanohydroxyapatite (n-HA) was deposited by calcium phosphate dipping method for BTE. Human mesenchymal stem cells (hMSCs) were cultured on these hybrid scaffolds to investigate the cell proliferation, osteogenic differentiation by alkaline phosphatase activity, mineralization, double immunofluorescent staining using CD90 and expression of osteocalcin. The present study indicated that the PCL/PAA/collagen/n-HA scaffolds promoted greater osteogenic differentiation of hMSCs, proving to be a potential hybrid scaffolds for BTE. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This article was published in Macromol Biosci and referenced in Journal of Drug Metabolism & Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords