alexa miR-15 and miR-16 induce apoptosis by targeting BCL2.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M,

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Abstract Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Cytology & Histology

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