alexa miRNA expression is highly sensitive to a drug therapy in Parkinson's disease.
Food & Nutrition

Food & Nutrition

Journal of Probiotics & Health

Author(s): Alieva AKh, Filatova EV, Karabanov AV, Illarioshkin SN, Limborska SA,

Abstract Share this page

Abstract BACKGROUND: miRNAs may play a role in the pathogenesis of Parkinson's disease. It is necessary to continue the search for new miRNAs that may affect the development of neurodegeneration in Parkinson's disease. METHODS: 20 untreated patients with Parkinson's disease and 18 treated patients with Parkinson's disease (Hoehn and Yahr scores 1-2) were studied. An analysis of the levels of 11 miRNAs in the peripheral blood lymphocytes of patients was carried out using reverse transcription followed by real-time PCR. RESULTS: The levels of miR-7, miR-9-3p, miR-9-5p, miR-129, and miR-132 were increased by more than three times in treated patients with Parkinson's disease compared with those of the controls. CONCLUSIONS: It is probable that miRNAs are very sensitive to drug therapy and that the effects of therapy observed may be associated with changes in the levels of these miRNAs and their target genes in patients with Parkinson's disease. Copyright © 2014 Elsevier Ltd. All rights reserved. This article was published in Parkinsonism Relat Disord and referenced in Journal of Probiotics & Health

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords