Author(s): Kolodner RD
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Abstract DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.
This article was published in Trends Biochem Sci
and referenced in Journal of Genetic Syndromes & Gene Therapy