alexa Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging and heart failure
Nursing

Nursing

Research & Reviews: Journal of Nursing and Health Sciences

Author(s): Hoppel CL, Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J

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Mitochondria contribute to cardiac dysfunction and myocyte injury via a loss of metabolic capacity and by the production and release of toxic products. This article discusses aspects of mitochondrial structure and metabolism that are pertinent to the role of mitochondria in cardiac disease. Generalized mechanisms of mitochondrial-derived myocyte injury are also discussed, as are the strengths and weaknesses of experimental models used to study the contribution of mitochondria to cardiac injury. Finally, the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) is addressed.

This article was published in J Mol Cell Cardiol and referenced in Research & Reviews: Journal of Nursing and Health Sciences

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