alexa Mitogen-activated protein kinases and their role in regulation of cellular processes.


Journal of Gerontology & Geriatric Research

Author(s): Strniskov M, Baranck M, Ravingerov T

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Abstract Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes connecting cell-surface receptors to critical regulatory targets within cells. The three major MAPK cascades are known, the extracellular signal-regulated protein kinase (ERK) cascade, c-Jun amino-terminal protein kinase/stress-activated protein kinase (JNK/SAPK) cascade and p38-MAPK cascade. This paper is focused on characterization of these MAPK cascades in terms of their distribution and biological role in some pathological processes (apoptosis, hypertrophy) with a special orientation on the role of MAPKs in cardiovascular system during ischemia/reperfusion.
This article was published in Gen Physiol Biophys and referenced in Journal of Gerontology & Geriatric Research

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