alexa Modeling the topology of protein interaction networks.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Schneider CM, de Arcangelis L, Herrmann HJ

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Abstract A major issue in biology is the understanding of the interactions between proteins. These interactions can be described by a network, where the proteins are modeled by nodes and the interactions by edges. The origin of these protein networks is not well understood yet. Here we present a two-step model, which generates clusters with the same topological properties as networks for protein-protein interactions, namely, the same degree distribution, cluster size distribution, clustering coefficient, and shortest path length. The biological and model networks are not scale-free but exhibit small-world features. The model allows the fitting of different biological systems by tuning a single parameter. This article was published in Phys Rev E Stat Nonlin Soft Matter Phys and referenced in Journal of Bioequivalence & Bioavailability

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