alexa Models for the incubation of AIDS and variations according to age and period.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Muoz A, Xu J, Muoz A, Xu J

Abstract Share this page

Abstract The objective of the methods proposed is to provide a parametric model for the incubation of AIDS and to use the chosen parameterization to test for the effect of age at seroconversion, and, after adjusting for markers of immunosuppression, to assess variations in periods corresponding to different levels of use of AIDS therapies at the population level. We compared the fit of Weibull, log-normal and three-parameter logistic models incorporating truncation in prevalent cohort and interval censored data. We showed the advantages by restricting the analysis to follow-up durations of greater than five years to improve estimation of the tail of the distribution for the prediction of long-term survivors. We applied the proposed methods to the combination of 1649 seroprevalent and 476 seroconverters with 1022 and 177 AIDS cases, respectively, who have been followed in the Multicenter AIDS Cohort Study (MACS) up to April 1995. Differences according to age at seroconversion are quantified in terms of relative percentiles and their associated 95 per cent confidence intervals were calculated using methods of multiple imputation. Using the proposed methods, we found that the log-normal model provides a fit as good as the three-parameter logistic; both are close to the non-parametric estimate and are significantly better than the fit of the Weibull model. We found that the older the age at seroconversion, the shorter the time to AIDS (relative percentile = 0.72 for age > or = 40 versus age < 25), and that the incubation of AIDS in calendar periods where treatment has been widely administered has been significantly longer among individuals with low CD4 cell counts.
This article was published in Stat Med and referenced in Journal of AIDS & Clinical Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords