Author(s): Handelsman J, Rondon MR, Brady SF, Clardy J, Goodman RM
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Abstract Cultured soil microorganisms have provided a rich source of natural-product chemistry. Because only a tiny fraction of soil microbes from soil are readily cultured, soil might be the greatest untapped resource for novel chemistry. The concept of cloning the metagenome to access the collective genomes and the biosynthetic machinery of soil microflora is explored here.
This article was published in Chem Biol
and referenced in Fungal Genomics & Biology