alexa Molecular biology of myelin proteins from the central nervous system.
Pediatrics

Pediatrics

Journal of Neonatal Biology

Author(s): Campagnoni AT

Abstract Share this page

Abstract Within the past several years, several of the genes coding for the major myelin proteins have been isolated, characterized, and mapped to specific chromosomes. In all cases, it has been clearly established that these proteins exist as multiple isoforms, and their structures have been established through an analysis of the cDNA clones encoding them. In each case, the isoforms appear to arise through the translation of individual mRNAs produced by alternative splicing of the primary transcript of a single gene. In several cases, the expression of the individual isoforms appears to be developmentally and/or regionally regulated, probably at the level of the splicing of the primary transcript. In the case of the dysmyelinating mutants shiverer and jimpy, the molecular defects involve the MBP gene and PLP gene, respectively; most of the dysmyelinating mutants, including those in which the genetic defect is established, appear to exhibit pleiotropy with respect to the expression of other myelin protein genes.
This article was published in J Neurochem and referenced in Journal of Neonatal Biology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 29th World Neonatal Nursing and Maternal Healthcare Congress
    August 28-30, 2017 Philadelphia, Pennsylvania, USA
  • 2nd International Conference on Pediatric Neurology
    August 31-September 01, 2017 Prague, Czech Republic
  • 10th World Pediatric Congress
    September 28-29, 2017 Dubai, UAE
  • Infancy, Child Nutrition & Development (ICND)
    October 16-18, 2017 (20 Forums, 3 Days- 1 Event) New York, USA
  • 20th International Conference on Neonatology and Perinatology
    December 04-06, 2017 Madrid, Spain

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords