alexa Molecular biomarkers of endocrine disruption in small model fish.
Toxicology

Toxicology

Journal of Environmental & Analytical Toxicology

Author(s): Scholz S, Mayer I, Scholz S, Mayer I

Abstract Share this page

Abstract A wide range of environmental contaminants can interfere with hormonal regulation in vertebrates. These endocrine disrupting chemicals (EDCs) are of high relevance for human and wildlife health, since endocrine signalling controls many essential physiological processes which impact on the individual's health, such as growth and development, stress response, and ultimately reproduction and population development. Small fish represent a cost-effective model for testing potential EDCs allowing the possibility to integrate from molecular to phenotypic and functional effects. We have comprehensively reviewed exposure-effect data from four different small model fish: zebrafish, medaka, fathead minnow, and the three-spined stickleback. The majority of available data refer to EDCs interfering with reproductive hormones. However, we have also included interactions with other hormone systems, particularly the thyroid hormones. We demonstrate that the available data clearly indicates the predictive potential of molecular biomarkers, supporting the development and regulatory application of simple molecular-based screening assays using small model fish for EDC testing. This article was published in Mol Cell Endocrinol and referenced in Journal of Environmental & Analytical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords