alexa Molecular, cellular, and physiological significance of N-terminal acetylation.


Molecular Biology: Open Access

Author(s): Aksnes H, Hole K, Arnesen T

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Abstract Protein N-terminal acetylation is catalyzed by N-terminal acetyltransferases and represents one of the most common protein modifications in eukaryotes. An increasing number of studies report on the importance of N-terminal acetylation for protein degradation, complex formation, subcellular targeting, and protein folding. N-terminal acetyltransferases are recognized to play important roles in a diversity of cellular processes like apoptosis, cell proliferation, sister chromatid cohesion, and chromatin silencing and are even linked to the development of rare genetic disorders and cancer. This article summarizes our current knowledge on the implications of N-terminal acetylation at the protein, cellular, and physiological levels. Copyright © 2015 Elsevier Inc. All rights reserved. This article was published in Int Rev Cell Mol Biol and referenced in Molecular Biology: Open Access

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